About Syntropic Medical™

Built on a belief that depression is reversible.

Syntropic Medical™ is a medical device company developing a new class of treatment for Major Depressive Disorder. We are building the evidence base, regulatory pathway, and clinical infrastructure to make neuroplasticity therapy a standard of care.

Our name comes from the concept of syntropy: the tendency of living systems to move toward greater order, complexity, and vitality. This is what we are helping restore in the brain.

Haven™ device on display

Our mission

To develop and deliver rapid neuroplasticity therapy as a standard of care for Major Depressive Disorder, and beyond.

Our approach

Rigorous science. Careful clinical development. A regulatory pathway built on evidence, not assumption.

Our ambition

To extend the platform to PTSD, Anxiety, and Sleep.

Our Manifesto

Depression is not simply a chemical imbalance.

It is a structural failure of the brain's ability to adapt.

To treat rigidity, we must restore flexibility.

This is what Syntropic Medical™ is built to do.

We are not building a better antidepressant. We are building a new treatment category. One grounded in the neuroscience of plasticity, validated through rigorous clinical evidence, and designed to be accessible at scale.

Mark Caffrey

Co-Founder & CEO

Jack O'Keeffe

Co-Founder & CTO

Recognition

Award-winning science.

Best of Biotech 2025 Winner
Creative Destruction Lab
Deep Tech Pioneer
Health Innovation World Cup
Top 12 Finalist
Best of Biotech 2025 Winner
Creative Destruction Lab
Deep Tech Pioneer
Health Innovation World Cup
Top 12 Finalist
Best of Biotech 2025 Winner
Creative Destruction Lab
Deep Tech Pioneer
Health Innovation World Cup
Top 12 Finalist
Best of Biotech 2025 Winner
Creative Destruction Lab
Deep Tech Pioneer
Health Innovation World Cup
Top 12 Finalist

Our team

The people behind Syntropic™.

Mark Caffrey

Mark Caffrey

Co-Founder and CEO

Co-founder of Syntropic Medical™. Leads commercial strategy, fundraising, and company operations.

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Jack O'Keeffe

Jack O'Keeffe

Co-Founder and CTO

Medical device engineer and co-founder. Leads product development, hardware engineering, and regulatory strategy for Haven™.

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Dr. Alessandro Venturino

Dr. Alessandro Venturino

Co-Founder and Head of Research

Neuroscientist and co-founder. Discovered the 60 Hz visual neuromodulation mechanism at ISTA. Leads the scientific research programme.

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Dr. Maria Teresa Ferretti

Dr. Maria Teresa Ferretti

Head of Clinical Development

Leads clinical program design, trial execution, and clinical partnerships across US and EU sites.

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Amin Alam

Amin Alam

Head of Engineering

Leads software, hardware, and AI development for Haven™. Drives device development from prototype to clinical-grade product.

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Dr. Friederike Leesch

Dr. Friederike Leesch

Senior Clinical Researcher

Neuroscientist specialising in neuroplasticity and perineuronal net biology. Supports the clinical research programme.

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Josh Rombot

Josh Rombot

Head of Operations

Leads back-office operations and infrastructure, enabling the company's scalable growth.

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Federica Montrone

Federica Montrone

Medical Device Engineer

Medical device engineer focused on quality control systems for Haven™.

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Prof. Dr. Sandra Siegert

Prof. Dr. Sandra Siegert

Co-Founder and Scientific Advisor

Professor at ISTA. Co-discoverer of the neuroplasticity mechanism underlying Haven™. Provides scientific oversight and advisory guidance.

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Investors

We welcome conversations with aligned investors.

Syntropic Medical™ is building a new treatment category in neuroscience. We are advancing a rigorous clinical programme, a clear regulatory pathway, and a platform with reach well beyond Major Depressive Disorder.

We are open to conversations with investors who understand the medtech development cycle, value evidence-based de-risking, and are interested in the intersection of neuroscience, mental health, and scalable medical devices.

If that describes you, we would like to speak.

[email protected]

2028

Regulatory clearance target

3

Trials active and completed

4

Patent families

4+

Indications in pipeline

Advisory Board

Guided by world-class expertise.

Jennifer Newberger

Jennifer Newberger

Regulatory Advisor

Medical device regulatory expert. Guides Syntropic's De Novo pathway and US market access strategy.

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Troy Dale

Troy Dale

Strategic Advisor

Strategic advisor and investor in Syntropic. Former head of neuroscience market access for Novartis.

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Fionn Lahart

Fionn Lahart

Strategic Advisor

CEO of Luma Vision. Chairperson of the Irish Medical Devices Association.

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Erika Ross Ellison

Erika Ross Ellison

Strategic Advisor

Head of clinical at Neuralink. Strategic advisor to Syntropic on Clinical & Quality.

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Dr. Leigh Charvet

Dr. Leigh Charvet

Clinical Advisor

Head of the NYU Neuromodulation Lab. Leading the HAVEN pilot program.

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Prof. Diego Pizzagalli

Prof. Diego Pizzagalli

Scientific Advisor

Founding director of the Institute for Translational Depression Discoveries, UC Irvine.

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Prof. André Brunoni

Prof. André Brunoni

Clinical Advisor

Chief of the division of Interventional Psychiatry, UT Southwestern. Lead Syntropic's feasibility study.

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What we stand for

Our values.

Evidence first

We build on published neuroscience. We do not make claims we cannot support. Every clinical decision is grounded in data.

Patients before everything

332 million people live with depression. That number drives every decision we make, from device design to regulatory strategy.

Radical honesty

We are building something genuinely new. We acknowledge what we know, what we are testing, and what we do not yet know.

Precision over speed

We are building a new treatment category. That requires patience, rigour, and the discipline to do it properly.

Open science

We publish our findings. We share our data. We believe the field advances faster when knowledge is shared.

Long-term thinking

We are not optimising for a quick exit. We are building a company that will still matter in 20 years, and beyond.

Get Involved

Rapid Neuroplasticity therapy for depression.

Join the clinical program. Partner with us.
Invest in the future of depression treatment.

Become a Founding Clinical SiteMeet our team

Syntropic Medical™

Plöcking 1, 3400 Klosterneuburg
Austria | AT U80004246

[email protected]

Haven™ is an investigational device. It has not been cleared or approved by the FDA or any regulatory authority. The clinical data presented on this website are from early-stage studies and are subject to change as our clinical program expands. © 2026 Syntropic Medical™ GmbH. All rights reserved.